Sunday, November 4, 2012

Developmental bait and switch

Saturday, November 3, 2012

During the early developmental stages of vertebrates?animals that have a backbone and spinal column, including humans?cells undergo extensive rearrangements, and some cells migrate over large distances to populate particular areas and assume novel roles as differentiated cell types. Understanding how and when such cells switch their purpose in an embryo is an important and complex goal for developmental biologists. A recent study, led by researchers at the California Institute of Technology (Caltech), provides new clues about this process?at least in the case of neural crest cells, which give rise to most of the peripheral nervous system, to pigment cells, and to large portions of the facial skeleton.

"There has been a long-standing mystery regarding why some cells in the developing embryo start out as part of the future central nervous system, but leave to populate peripheral parts of the body," says Marianne Bronner, the Albert Billings Ruddock Professor of Biology at Caltech and corresponding author of the paper, published in the November 1 issue of the journal Genes & Development. "In this paper, we find that an important type of enzyme called DNA-methyltransferase, or DNMT, acts as a switch, determining which cells will remain part of the central nervous system, and which will become neural crest cells."

According to Bronner, DNMT arranges this transition by silencing expression of the genes that promote central nervous system (CNS) identity, thereby giving the cells the green light to become neural crest, migrate, and do new things, like help build a jaw bone. The team came to this conclusion after analyzing the actions of one type of DNMT?DNMT3A?at different stages of development in a chicken embryo.

This is important, says Bronner, because while most scientists who study the function of DNMTs use embryonic stem cells that can be maintained in culture, her team is "studying events that occur in living embryos as opposed to cells grown under artificial conditions," she explains.

"It is somewhat counterintuitive that this kind of shutting off of genes is essential for promoting neural crest cell fate," she says. "Embryonic development often involves switches in the types of inputs that a cell receives. This is an example of a case where a negative factor must be turned off?essentially a double negative?in order to achieve a positive outcome."

Bronner says it was also surprising to see that an enzyme like DNMT has such a specific function at a specific time. DNMTs are sometimes thought to act in every cell, she says, yet the researchers have discovered a function for this enzyme that is exquisitely controlled in space and time.

"It is amazing how an enzyme, at a given time point during development, can play such a specific role of making a key developmental decision within the embryo," says Na Hu, a graduate student in Bronner's lab and lead author of the paper. "Our findings can be applied to stem cell therapy, by giving clues about how to engineer other cell types or stem cells to become neural crest cells."

Bronner points out that their work relates to the discovery, which won a recent Nobel Prize in Medicine or Physiology, that it is possible to "reprogram" cells taken from adult tissue. These induced pluripotent stem (iPS) cells are similar to embryonic stem cells, and many investigators are attempting to define the conditions needed for them to differentiate into particular cell types, including neural crest derivatives.

"Our results showing that DNMT is important for converting CNS cells to neural crest cells will be useful in defining the steps needed to reprogram such iPS cells," she says. "The iPS cells may in turn be useful for repair in human diseases such as familial dysautonomia, a disease in which there is depletion of autonomic and sensory neurons that are neural crest?derived; for repair of jaw bones lost in osteonecrosis; and for many other potential treatments."

In the short term, the team will explore the notion that DNMT enzymes may have different functions in the embryo at different places and times. That's why the next step in their research, says Bronner, is to examine the later role of these enzymes in nervous-system development, like whether or not they effect the length of time during which the CNS is able to produce neural crest cells.

###

California Institute of Technology: http://www.caltech.edu

Thanks to California Institute of Technology for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 64 time(s).

Source: http://www.labspaces.net/125019/Developmental_bait_and_switch

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Saturday, November 3, 2012

How the negative trumps the positive in politics

Friday, November 2, 2012

Negatively framed political attitudes ("I don't like Obama") are stronger than positively framed attitudes ("I like Romney"), and this effect is strengthened when people think more deeply about the issues involved.

That is the finding of a paper published in the latest issue of the British Journal of Social Psychologyby George Bizer, a psychology professor at Union College in Schenectady, N.Y.

Bizer and his co-authors Iris ?e?elj (University of Belgrade) and Jamie Luguri (Yale University) presented participants with information about two fictional (though ostensibly real) candidates ? one conservative, one liberal ? for a position on a government board.

After reading about the two candidates, some participants were asked if they 'supported' or 'opposed' the liberal candidate and some were asked if they 'supported' or 'opposed' the conservative. When the candidates were vying for a local government board, participants who were led to frame their opinions negatively ? regardless of their underlying preference ? expressed more certainty about their attitudes than did participants who were led frame their opinions positively. When the candidates were vying for a distant government board, the effect did not emerge.

Follow-up experiments replicated these findings: Experiment 2 showed that opposers were more certain than supporters, but only when the participants were able to think carefully about the candidates, while Experiment 3 showed that the effect generalized to perceived importance.

Dr Bizer says: "Our prior research showed that framing an opinion in terms of opposition yields stronger attitudes than does framing it in terms of support.

The most interesting point from our latest research is that this effect is actually stronger when people process the messages more deeply ? when they are motivated and have been able to think about the issue. But when people are not motivated and able, the effect goes away. So, perhaps counter-intuitively, the people who care the most about the issues or candidates seem more likely to be affected by the bias."

###

Union College: http://www.union.edu

Thanks to Union College for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 45 time(s).

Source: http://www.labspaces.net/125013/How_the_negative_trumps_the_positive_in_politics

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Comment: An eye for an eye | Minivan News

Comment: An eye for an eye thumbnail

In times of huge social stress, societies look for extraordinary solutions to growing social problems. The economic and social collapse in the Weimar Republic, after the First World War, helped the Nazi ideology to flourish in Germany.

In the post-coup Maldives, the issue of escalating violence and violent murders have encouraged many to look for quick fixes that may reverse this frightening trend.

The death penalty is gaining ground as a proposed solution to the current problems of the Maldives. The media reports that the government has announced its intentions to introduce a bill ?to guide and govern the implementation of the death penalty in the country?.

But, before we resort to such drastic measures, it may be prudent to pause and consider if capital punishment would prove to be the miracle cure that the nation is looking for.

?An eye for an eye? or ?a tooth for a tooth? has a comforting simplicity. It seems an elegant equation which promises unequivocal justice. But, here?s the rub: capital punishment is an ethical quagmire and justice, in any comprehensive form, may be the last thing it is equipped to deliver.

Justice and the death penalty

The question of justice is an appropriate starting point when considering the death penalty. It is often argued that life imprisonment is not an adequate punishment for a killer, that the crime of taking a life should forfeit the killer?s own fundamental human right to live.

However, the sentencing of the death penalty works on the premise that a fair, transparent and comprehensive process of justice has preceded the verdict. This pre-requisite must surely raise alarm bells in the minds of thinking Maldivians.

The Maldives is not a just state. There is a general consensus in the country that the justice system needs drastic reshaping for it to function in a fair and just way. The long list of human rights abuses in the last 30 years through to the present time has been well documented. In the name of law and order, people are beaten, pepper sprayed, and tossed into prison with impunity. Amnesty International reports the existence of ?a human rights crisis that has gripped the country? since the February 7 coup.

Selective justice is the other complicating factor in considering the death penalty in the Maldives. Justice has become a political game. Trials of the regime?s political opponents are given prominence, while thousands of more vital cases pile up on the scrap-heap that is the present justice system of the country. Meanwhile crimes committed by police officers who went on a binge of destruction and violence on February 7 are tidily packed away into the background. There is a general acceptance that the agenda of the regime, in collusion with the MPS (Maldives Police Service) and MNDF (Maldives National Defence Force), is perilously political. The possibility of this regime adding the death penalty to its arsenal is a daunting thought indeed.

The judiciary in the Maldives is the embodiment of all these perversions of justice and more. Controlled by the iron grip of an authoritarian regime for over thirty years, the judiciary has not even allowed justice to be seen to be done. In a country where people boasts about having the highest ratio of doctorates per head of the population, and one of the highest literacy rates in South East Asia, the competence and qualifications of Maldive?s judges remain akin to the apothecaries of the Dark Ages.

No doubt it is easier for a government to influence the course of ?justice? if the judiciary is kept in a state of perpetual ignorance. But, in the process, it has lost any credibility in the eyes of Maldivians and international observers. A litany of wrong doings, including frightening ethical and moral lapses, hangs around the neck of the Chief Judge of the Criminal Court, Judge Abdulla Mohamed. Notwithstanding, the regime has seen it fit to keep him in his job.

However, in issues of the death penalty, even the world?s most advanced legal systems risk fallibility. This is why many of them reject the death penalty as a solution to societal violence. In the case of the Maldives, multiple reports, including the work of legal expert Professor Paul Robinson, have shown the legal system to be ?systematically failing to do justice and regularly doing injustice?.

The country also lacks the trained personnel and the technology that underpins reliable criminal investigations. One of the gravest dangers of capital punishment is its potential for miscarriages of justice. With the justice system so compromised, legalising the death penalty in the Maldives would be as dangerous as giving a box of matches to a toddler in a room packed with gun powder.

The death penalty as a deterrent

The jury is still out on the question of whether the death penalty acts as a viable deterrent for murder and other violent crimes. The screeds of research and literature regarding the pros and cons of the death penalty match the strong emotional responses that the issue evokes.

However, a wealth of research indicates that the death penalty can contribute to more violence through a ?brutalization effect? on the public; it desensitizes people and increases the chance of the general public accepting violence as a way of solving problems. In this context, it is pertinent to note that murder rates in death-penalty states in America are consistently higher than the murder rates in non- death penalty states.

Research also suggests that there is an ?imitation effect? where people believe that if their leaders can legitimately kill people, through legalising capital punishment, so can they. This is extremely significant to the Maldives. The present surge of violent murders has taken place since the February 7 coup where members of the security forces participated in what many commentators described as ?widespread brutality?.

There is a wealth of evidence to bring the culprits to justice, but nothing has been done and it would seem, can be done ? if the status quo is to remain. In this atmosphere of state ? condoned violence-and the moral and ethical disorientation it creates ? is it any wonder that the criminal elements of the society are thriving?

Changing the paradigm

When governments are faced with harrowing internal problems, for which they have no creative answers, their first reaction is to shift the public focus away from the real issues. This is often done through the introduction of contentious topics of debate either in parliament or the media. The intention is to shift the focus from the real problems and engage the populous in heated debate which diverts the energy and attention from the real problems that the government is not equipped to cope with.

It is important, therefore, that we identify where the focus of our debate should be. Experience teaches us that ?miracle cures? for entrenched societal ills do not exist. It is convenient to think that capital punishment will halt the escalation of violent murders, but at the very best, it will turn out to be the ambulance at the bottom of the cliff. Positive change requires more than a law. It requires more than political rhetoric. It requires more than clever manipulation to hide egregious social issues, by highlighting others.

Rather than a law legitimising the death penalty, our society needs the rule of law. The rule of law in the Maldives has been described by one cynic as ?a cancer patient kept alive by drug.? When the law enforcers who have promised ?to protect and serve? wear balaclavas to beat and brutalise people, it is not hard to surmise that Maldives, especially Male, is a ?frontier town? where the rule of law has been hijacked by the rule of might.

We need the leaders of the nation to show the people that they are honest, just and capable. The economic collapse of the country is not the only sign of the regime?s inability to lead. The murder of Dr Afrasheem Ali is a huge tragedy, regardless of what side of the political divide we have positioned ourselves. It is an execution style murder, accomplished with such brutality, that even the young and the able-bodied are questioning their safety; the old and the disabled having long blockaded themselves behind doors. These are all tragic, but the greater tragedy is the lack of an appropriate response by the government.

We need justice to function as a powerful and active force in the daily lives of our people. The most stable and safe societies in the world are those where the people feel the presence of a strong sense of justice. This stage of stability is not achieved overnight, nor is it arrived at by the threat of more punishment. It is the end product of enlightened and fair governance, which in turn produces a strong sense of nationhood based on shared values and aspirations. When justice falters, society collapses.

More than ever, we need to realise that a nation cannot function effectively, if its wealth is monopolised by a privileged few. Discounting a short period of time between 2008 and 2011, the state Maldives had grievously failed to address the needs of it citizenry. Research shows that a low standard of living is not as socially damaging as a huge disparity between the ?have? and ?have nots?. When we view the dystopia we have created, it is important to remember that a community is only as strong as its weakest link. Social problems such as crime, violence and drug-abuse often surrounding the disfranchised and the alienated, affect the whole society. This is especially problematic in a geographically small place such as the Maldives.

The people and the society they live in are entwined in a complex web of interrelationships. Ralph Waldo Emerson wrote that, ?Society is inside of man and man is inside society? The fish is in the water and the water is in the fish?. We need to examine the water that is inside the fish in Maldivian society. When we do so, how can we escape the gloomy conclusion that the water inside the fish is exceptionally murky? The lack of honest leadership with a view for the betterment of its people, the collapse of the justice system, the lack of personal freedom and democratic rights, as well as the abuse of human rights with impunity, have all contributed to this.

Until the water clears, the death penalty is simply another dangerous tool in the hands of the wrong people.

All comment pieces are the sole view of the author and do not reflect the editorial policy of Minivan News. If you would like to write an opinion piece, please send proposals to editorial@minivannews.com


Source: http://minivannews.com/society/comment-an-eye-for-an-eye-46625

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Web Hosting Services Supplied By The Businesses Benefiting The ...

Along with the explosion of social websites and therefore the rising worldwide recognition of world-wide-web video clip, it only is sensible that both of these web-based units meld jointly to make the supreme online marketing software? The movies now hold the power to require a lifetime of their own individual and distribute significantly and huge throughout the world wide web searching local community via these social websites internet sites with any kind of topic make any difference. Video clips consist of an a variety of benefits, apart from the capability to realize viral position, they are simply also affordable, permit the conversation of the enormous amount of knowledge inside of a quick time, is way significantly more preferable to look at than for somebody to study a wall of text on the web site, along with remaining equipped to build a human link and appropriately lending a deal with and character to an or else bland concept.

The fact is all of us thinks which they can deliver a video clip, but delivering a high-quality and efficient online video could in fact be much more tough than some may perhaps figure out. This really is where exactly the certified video clip creation agency arrives in. Whereas employing an online video development service can relieve a great deal of the power that goes into these endeavors, one can find nonetheless most choices that should ought to be built in the past filming may even commence. In an effort to build an output procedure that goes as easy and pain-free as is possible, right here are 5 quick steps which could support guidebook the manufacturing stage to make certain all the pieces goes as seamlessly as you possibly can.

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This idea is integral for the good results of any promotion marketing campaign. Free of comprehending your viewers, you won?t have the option to build an efficient script or solution which can perform in the must have of one?s specific. Free of being familiar with who you will be participating in to, the entire theory is usually a shot during the darkish.

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Before you decide to make any precise generation designs, make sure you make up your mind what sort of video clip you may need to help make, in which you have to movie it, want what concept you would like to convey. Determine this out primary, will help you save appreciable effort and time later on on simply because you would not really need to return and refigure whatever you have to have.

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Never ever toss an internet video clip collectively from scratch. That is a certain recipe for failure. Without the need of aquiring a diligently scripted movie or simply a rehearsal will only be certain that the movie will learn dry and flat, ensuing in no temperament for ones online site.

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To increase the very last place, if you are setting up your video?s material, you have got to preserve the fabric transient and rather simple. Generating an online video much too extensive will put on out your viewer and may appear as well monotonous and also you operate the danger of shedding their focus permanently.

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Despite even if or not the prior techniques are already adopted, it?s the fine quality which makes or breaks the entire movie. The 1st matter that is definitely judged on would be the total start looking how the movie is done; if its shaky, the lights is off, or even the audio is very poor.This all influences in case the viewers will choose an online video significantly or not.

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How Presidential Elections Made Social Media Marketing Banal ...

As we approach the final days of the U.S. presidential campaign, all the media attention shifts to the ground game: how many doors are knocked, and how many voters are mobilized in crucial swing states like Ohio. But while field organizing is essential in this closely contested race, the groundwork has been laid over many months by the campaigns' digital operations.

Online outreach has enabled the candidates to raise vast sums of money, identify their supporters and likely supporters with precision, and leverage social networks to engage peer pressure (the more polite term from psychology is "social proof") on their behalf. And though the campaigns' digital efforts have received far less notice this time around compared to President Obama's much-ballyhooed effort in 2008, businesses can still extract many important (and little-noticed) lessons from this year's online contest.

Here are some of the most salient, which I discussed in a session I moderated last week at the Inbound Marketing Summit on "Digital Marketing in the Political Arena," guest-starring Harvard Kennedy School professor Nicco Mele and fellow HBR blogger Michael Schrage, who recently wrote an astute piece about polling.

You can thrive on constraints. Everyone knows politics is a big money game. In fact, a recent New York Times article revealed that nearly $6 billion will be spent on this year's election. But most of that money goes to high-priced television ads ? and on every other front, campaigns are as cheap as they come. (On the presidential campaign where I served as spokesperson, we were forced to raise the pay of our field organizers midway through the campaign because it turned out we had been violating minimum-wage laws.) That's why online media has been such a perfect match for the world of political campaigns: though it takes time and strategy, it doesn't take much money. Just as Nancy Lublin suggested in her book Zilch: The Power of Zero in Business, corporations have a lot to learn from underfunded nonprofits, and the same is true of political campaigns. Great online efforts can thrive with creativity and brainpower, even sans capital.

Novelty fades fast. During the 1996 election cycle, campaigns could literally get media coverage because they had a website; it was that unusual. By 2000, there were glimpses of websites' practical value, as when John McCain had a fundraising windfall in the days after his New Hampshire primary victory. In 2004 and 2008, the media gobbled up stories of the online prowess of the Howard Dean and Barack Obama campaigns, highlighting alluring new tools like Meetup, blogs, and text message marketing. Today, that process-based coverage is largely gone. In a little more than a decade, online tools have gone from novel to fashionable to completely unexceptional. You have to move fast to keep up, and the bar is getting higher.

Everyone has to play. Barack Obama's digital infrastructure is legendary. He ran a well-regarded online campaign in 2008, nurtured it during the intervening years, and throughout this election cycle has understandably held a formidable advantage over the Romney campaign: 31 million Facebook likes to Romney's 11 million, and 21.5 million Twitter followers to Romney's 1.6 million, as of the beginning of November. But it's clear that online operations have become so central to political success, everyone has to play: Romney simply cannot afford to cede the advantage and focus elsewhere. Indeed, AdAge revealed Romney has a whopping 110 staffers focused on digital efforts. And wherever possible, his campaign has tried guerrilla online actions against Obama, including making early use of Sponsored Results on Facebook, which presented viewers with Romney ads when they searched for the president.

You're not controlling the message, but you can (and should) try. It's been clear for a while that social media has allowed individuals access to a megaphone they never had in the broadcast era. But the sea change is only now becoming evident. A study by Bluefin Labs showed there were 7 million public comments on Facebook and Twitter in response to television coverage of the conventions ? 2.5 million of them in the final 90 minutes of the Democratic Convention. That's a tidal wave of public input, and it makes it much harder to shape the narrative, the traditional goal of campaign press departments. But that doesn't mean they aren't trying. After getting hammered by the press and most commentators for his lackluster performance during the first debate, Obama's campaign wasn't going to take any chances during the second one at Hofstra University in New York. In what was viewed as an effort to shape discussion and, essentially, distribute early talking points, his team tweeted a remarkable 37 times during the course of the 90 minute debate, leveraging 117,000 retweets. If there's a deluge of conversation, they're going to at least try to be part of it.

By itself, digital won't win elections ? or, for that matter, sell your product or service. It has limitations (as Nicco Mele pointed out during our session, it's still much better for rallying committed supporters rather than for persuading new ones). But it's also become a mandatory, even banal, part of campaign infrastructure. The sexiness of Internet tools has worn off ? but their emerging importance in meeting your ultimate goals, whether in politics or business, cannot be overstated.

Source: http://blogs.hbr.org/cs/2012/11/how_presidential_elections_made_social_media_marketing_banal.html

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Alpha Natural Resources 3Q loss less than expected

NEW YORK (AP) ? Shares of Alpha Natural Resources jumped 7 percent Friday after the coal producer narrowed its losses and posted much better earnings than were expected for the third quarter as the industry struggles with anemic demand.

The company lost $46.1 million, or 21 cents per share, compared with a year-earlier quarterly profit of $62.6 million, or 28 cents per share.

Revenue fell 29 percent to $1.63 billion.

Analysts polled by FactSet expected a loss of 45 cents per share with revenue of $1.69 billion.

Alpha Natural and other coal producers are being hit by a double whammy of weak demand. Utilities need less coal to produce electricity because of mild weather and lower power generation, while construction overseas has slowed the appetite for coal to make steel.

"In the face of these market headwinds, Alpha has taken swift and decisive actions to right-size our operational footprint and our cost structure," the company said in a statement.

That includes slowing production to get more in line with demand as prices continue to fall and the slashing of about 1,200 jobs. The restructuring started in September and is expected to save $150 million a year once they're complete.

Shares of Alpha Natural Resources Inc. rose 65 cents to $9.51 in trading before the opening bell.

Source: http://news.yahoo.com/alpha-natural-resources-3q-loss-less-expected-132732637--finance.html

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Video: Reid: Vick is the starter, period

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Source: http://nbcsports.msnbc.com/id/21134540/vp/49651139#49651139

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